Amyloid Imaging and Cognitive Impairment After Intracerebral Hemorrhage
Description
Brief Summary
To evaluate Pet AV-45 Amyloid imaging in the etiological diagnosis of primary non traumatic
intracerebral hemorrhage (Cerebral Amyloid Angiopathy and hypertension related hemorrhage).We
hypothesize that patients with lobar hemorrhage (probably related to Cerebral Amyloid
Angiopathy) will have a greater AV45 cortical binding than patients with deep hemorrhage
(probably related to hypertension).
Detailed Description
Cerebral Amyloid Angiopathy (CAA) and hypertension related hemorrhage are the main causes of
non traumatic primary intracerebral hemorrhage. In vivo diagnosis of these two cerebral
diseases may be difficult and is based on hematoma location and pattern of cerebral
microbleeds (CMB) distribution. We aimed to evaluate a multimodal approach including brain
MRI, Pet AV-45 Amyloid imaging and neuropsychological assessment to improve etiological
diagnosis of primary intracerebral hemorrhage. 70 patients with acute primary non traumatic
intracerebral hemorrhage will be prospectively included and two groups will be compared:
lobar hemorrhage group and deep hemorrhage group. Brain MRI, Pet AV-45 Cerebral Amyloid
imaging (during the first month) and neuropsychological assessment (Three months later) are
performed. Differences between the two groups are evaluated for AV45 cortical binding, CMB
distribution, White Matter Lesions and cognitive profile.
Phase
Phase 2 - takes the treatment one step further, assessing the activity of a particular therapy in a disease, often building upon leads from the Phase I trial. While patients are generally required to be previously untreated, participation in a Phase II trial doesn't usually preclude the patient from getting the standard treatment after they've received the investigational agent. At best they are allowed to get a new drug they wouldn't be able to get otherwise that may turn out to be better for their disease.Inclusion and Exclusion Criteria
- Age : 40-90 years,
- Non traumatic primary intracerebral hemorrhage during acute phase (less than 30 days from hemorrhage onset) confirmed on brain imaging (CT and/or MRI).
- Correct visual, hearing and language functions to perform neuropsychological tests.
- Written consent of patient
- Secondary causes of intracerebral hemorrhage : vascular malformations (Arteriovenous malformation, intracranial aneurysm, Cavernous angioma, dural arteriovenous fistula), cerebral venous thrombosis, intracranial neoplasm, coagulopathy, vascularitis, Cocaine or alcohol use, Hemorrhagic ischemic stroke.
- Pregnancy
- Contraindication to MRI
- progressive neoplasm
- Cognitive impairment secondary to progressive neurological disease
- Depression,
- Drug addiction
Sites
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