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CTSU/NSABP-B43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy

Description

PRIMARY OBJECTIVES: I. To determine the value of trastuzumab given during radiation therapy (RT) compared to RT alone in preventing subsequent occurrence of ipsilateral breast cancer recurrence, ipsilateral skin cancer recurrence, or ipsilateral ductal carcinoma in situ (IIBCR-SCR-DCIS) in women with human epidermal growth factor receptor 2 (HER2)-positive DCIS resected by lumpectomy. SECONDARY OBJECTIVES: I. Determine the value of trastuzumab given during RT compared to RT alone in prolonging invasive or DCIS disease-free survival (IDFS)-DCIS. II. Determine the value of trastuzumab given during RT compared to RT alone in increasing invasive or DCIS recurrence-free interval. III. Determine the value of trastuzumab given during RT compared to RT alone in improving regional or distant recurrence. IV. Determine the value of trastuzumab given during RT compared to RT alone in improving the incidence of contralateral invasive or DCIS breast cancer. V. Determine the value of trastuzumab given during RT compared to RT alone in improving survival. VI. To explore the effect of trastuzumab on ovarian function. TERTIARY OBJECTIVES: I. To determine if the benefit of trastuzumab added to RT will be significantly higher in v-myc avian myelocytomatosis viral oncogene homolog (cMYC)-amplified tumors than in the cMYC non-amplified subset. II. To determine if the benefit of trastuzumab added to RT will be less in tumors with mutations in the phosphatidylinositol 3 (PI3) kinase gene than in tumors without PI3 kinase gene mutations. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM I: Patients undergo standard whole breast irradiation (WBI) over 5-6 weeks. ARM II: Patients receive trastuzumab intravenously (IV) over 30-90 minutes once in weeks 1 and 4. Patients also undergo WBI as in Arm I. After completion of study treatment, patients are followed up every 6 months for 5 years and then every 12 months for 5 years.

Phase

Phase 3 - a treatment has shown activity against a particular disease, where it is either added to existing treatment or compared to the standard treatment.

Inclusion and Exclusion Criteria

  • The patient must have consented to participate and must have signed and dated an appropriate Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines for the study treatment and for the pre-entry tumor block submission for HER2 testing and B-43 correlative studies
  • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (0 = fully active, able to carry on all pre-disease performance without restriction; 1 = restricted in physically strenuous activity but ambulatory)
  • On histologic examination, the tumor must be ductal carcinoma in situ (DCIS) (patients with mixed DCIS and lobular carcinoma in situ [LCIS] are eligible)
  • The DCIS must be HER2-positive as determined by central testing
  • Estrogen and/or progesterone receptor status must be determined prior to randomization (patients with DCIS that is hormone receptor positive or negative are eligible)
  • All DCIS must have been resected by lumpectomy
  • The margins of the resected specimen must be histologically free of DCIS; for patients in whom pathologic examination demonstrates DCIS present at the line of resection, re-excision(s) may be performed to obtain clear margins (patients who require mastectomy are not eligible)
  • If axillary staging is performed, nodal staging must be pN0, pN0(i-), pN0(i+) which is defined as isolated tumor cells =< 0.2 mm, regardless of the method of detection, i.e., immunohistochemistry (IHC) or hematoxylin & eosin (H&E), pN0(mol-), or pN0(mol+); note: axillary staging is not required
  • The interval between the last surgery for excision of DCIS (lumpectomy or re-excision of lumpectomy margins) and randomization must be no more than 120 days

  • Invasive (including microinvasion staged as T1mic) breast cancer (patients with DCIS "suspicious" for microinvasion, but not confirmed, are eligible)
  • Nodal staging of pN1 (including pN1mi) (note: axillary staging is not required)
  • DCIS present in more than one quadrant (multicentric)
  • Masses or clusters of calcification that are clinically or mammographically suspicious unless biopsied and proven to be benign (if DCIS is found, the patient is eligible if the DCIS was in the same quadrant of the ipsilateral breast and was resected with clear margins)
  • Contralateral breast cancer (including DCIS)
  • Whole breast irradiation administered before randomization (partial breast irradiation is prohibited)
  • Prior history of breast cancer, including DCIS (patients with a history of LCIS are eligible)
  • Prior anthracycline chemotherapy for any malignancy
  • Cardiac disease that would preclude the use of the drugs included in the B-43 treatment regimens; this includes but is not confined to:
  • Active cardiac disease:
  • Angina pectoris that requires the use of anti-anginal medication;
  • Ventricular arrhythmias except for benign premature ventricular contractions (PVCs) controlled by medication;
  • Conduction abnormality requiring a pacemaker;
  • Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; and
  • Clinically significant valvular disease
  • History of cardiac disease:
  • Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
  • Documented congestive heart failure; or
  • Documented cardiomyopathy
  • Uncontrolled hypertension, i.e., systolic blood pressure [BP] greater than 180 mm/Hg and/or diastolic BP greater than 100 mm/Hg (patients with hypertension that is well controlled on medication are eligible)
  • Other nonmalignant systemic disease that would preclude a patient from receiving trastuzumab or radiation therapy or would prevent prolonged follow-up
  • Other malignancies unless the patient is considered to be disease-free for 5 or more years prior to randomization and is deemed by her physician to be at low risk for recurrence; patients with the following cancers are eligible if diagnosed and treated within the past 5 years: carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell carcinoma of the skin
  • Pregnancy or lactation at the time of study entry (note: pregnancy testing according to institutional standards should be performed for women of child-bearing potential)
  • Administration of any investigational agent within 30 days before study entry

Sites

  • California

    • Kaiser Permanente, Los Angeles, California, 90027
    • Kaiser Permanente, Los Angeles, California, 90027
    • Glendale Memorial Hospital and Health Center, Glendale, California, 91204
    • Glendale Memorial Hospital and Health Center, Glendale, California, 91204
    • Huntington Memorial Hospital, Pasadena, California, 91105
    • Huntington Memorial Hospital, Pasadena, California, 91105
    • Cedars-Sinai Medical Center, Los Angeles, California, 90048
    • Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, 91505
    • Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, 91505
    • Long Beach Memorial Medical Center-Todd Cancer Institute, Long Beach, California, 90806
    • Long Beach Memorial Medical Center-Todd Cancer Institute, Long Beach, California, 90806
    • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California, 90095
    • University of California at Los Angeles Health System, Los Angeles, California, 90095
    • Saint Jude Medical Center, Fullerton, California, 92835
    • Saint Joseph Hospital - Orange, Orange, California, 92868
    • University of California Medical Center At Irvine-Orange Campus, Orange, California, 92868
    • Breastlink Medical Group Inc, Santa Ana, California, 92705
    • Breastlink Medical Group Inc, Santa Ana, California, 92705
    • Loma Linda University Medical Center, Loma Linda, California, 92354
    • Loma Linda University Medical Center, Loma Linda, California, 92354
    • Cancer Center of Santa Barbara, Santa Barbara, California, 93105
    • Cancer Center of Santa Barbara, Santa Barbara, California, 93105
    • UC San Diego Moores Cancer Center, La Jolla, California, 92093
    • University of California San Diego, San Diego, California, 92103
    • University of California San Diego, San Diego, California, 92103
    • Saint Agnes Medical Center, Fresno, California, 93720
    • California Cancer Center - North Fresno, Fresno, California, 93720
    • Saint Agnes Medical Center, Fresno, California, 93720
    • Salinas Valley Memorial, Salinas, California, 93901
    • Salinas Valley Memorial, Salinas, California, 93901
    • Memorial Medical Center, Modesto, California, 95355
    • Memorial Medical Center, Modesto, California, 95355
    • Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California, 95065
    • Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California, 95065
    • Palo Alto Medical Foundation-Camino Division, Mountain View, California, 94040
    • Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View, California, 94040
    • Palo Alto Medical Foundation-Camino Division, Mountain View, California, 94040
    • Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View, California, 94040
    • Washington Hospital, Fremont, California, 94538
    • Washington Hospital, Fremont, California, 94538
    • Stanford University Hospitals and Clinics, Stanford, California, 94305
    • Palo Alto Medical Foundation Health Care, Palo Alto, California, 94301
    • Palo Alto Medical Foundation Health Care, Palo Alto, California, 94301
    • Valley Care Health System - Pleasanton, Pleasanton, California, 94588
    • Valley Care Health System - Pleasanton, Pleasanton, California, 94588
    • Eden Hospital Medical Center, Castro Valley, California, 94546
    • Eden Hospital Medical Center, Castro Valley, California, 94546
    • Mills - Peninsula Hospitals, Burlingame, California, 94010
    • John Muir Medical Center, Walnut Creek, California, 94598
    • John Muir Medical Center, Walnut Creek, California, 94598
    • Kaiser Permanente Oakland-Broadway, Oakland, California, 94611
    • John Muir Medical Center-Concord Campus, Concord, California, 94520
    • John Muir Medical Center-Concord Campus, Concord, California, 94520
    • Bay Area Tumor Institute, Oakland, California, 94609
    • Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, 94704
    • California Pacific Medical Center-Pacific Campus, San Francisco, California, 94118
    • Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, 95682
    • Palo Atlo Medical Foundation-Sunnyvale, Sunnyvale, California, 94806
    • Palo Atlo Medical Foundation-Sunnyvale, Sunnyvale, California, 94806
    • Mercy General Hospital Radiation Oncology Center, Sacramento, California, 95819
    • Sutter General Hospital, Sacramento, California, 95816
    • Northbay Cancer Center, Fairfield, California, 94533
    • Northbay Cancer Center, Fairfield, California, 94533
    • Marin General Hospital, Greenbrae, California, 94904
    • Marin Cancer Care Inc, Greenbrae, California, 94904
    • Marin General Hospital, Greenbrae, California, 94904
    • Marin Cancer Care Inc, Greenbrae, California, 94904
    • Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, 95687
    • Sutter Roseville Medical Center, Roseville, California, 95661
    • Sutter Roseville Medical Center, Roseville, California, 95661
    • Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, 95661
    • Sutter Davis Hospital, Davis, California, 95616
    • Sutter Davis Hospital, Davis, California, 95616
    • Sutter Cancer Research Consortium, Novato, California, 94945
    • Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, 95603
    • Sutter Auburn Faith Hospital, Auburn, California, 95602
    • Sutter Auburn Faith Hospital, Auburn, California, 95602
    • Rohnert Park Cancer Center, Rohnert Park, California, 94928
    • Saint Helena Hospital, Saint Helena, California, 94574
    • Sutter Pacific Medical Foundation, Santa Rosa, California, 95403
    • Feather River Cancer Center, Paradise, California, 95969
    • Feather River Cancer Center, Paradise, California, 95969
  • Nevada

    • 21st Century Oncology - Fort Apache, Las Vegas, Nevada, 89148
    • Cancer and Blood Specialists-Fort Apache, Las Vegas, Nevada, 89148
    • HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas, Nevada, 89113
    • Summerlin Hospital Medical Center, Las Vegas, Nevada, 89144
    • Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas, Nevada, 89144
    • Summerlin Hospital Medical Center, Las Vegas, Nevada, 89144
    • Las Vegas Cancer Center-Henderson, Henderson, Nevada, 89052
    • Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada, 89052
    • Cancer and Blood Specialists-Henderson, Henderson, Nevada, 89052
    • Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, 89128
    • HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas, Nevada, 89128
    • Cancer and Blood Specialists-Tenaya, Las Vegas, Nevada, 89128
    • Radiation Oncology Centers of Nevada Southeast, Las Vegas, Nevada, 89119
    • Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson, Nevada, 89074
    • 21st Century Oncology - Henderson, Henderson, Nevada, 89074
    • 21st Century Oncology - Vegas Sunrise, Las Vegas, Nevada, 89109
    • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas, Nevada, 89109
    • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas, Nevada, 89149
    • Cancer and Blood Specialists-Shadow, Las Vegas, Nevada, 89106
    • Cancer Therapy and Integrative Medicine, Las Vegas, Nevada, 89121
    • Renown Regional Medical Center, Reno, Nevada, 89502
  • Utah

    • Dixie Medical Center Regional Cancer Center, Saint George, Utah, 84770
    • Sandra L Maxwell Cancer Center, Cedar City, Utah, 84720
    • Sandra L Maxwell Cancer Center, Cedar City, Utah, 84720
    • Utah Valley Regional Medical Center, Provo, Utah, 84604
    • American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah, 84003
    • Huntsman Intermountain Cancer Center-American Fork Hospital, American Fork, Utah, 84003
    • Intermountain Medical Center, Murray, Utah, 84157
    • Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah, 84106
    • LDS Hospital, Salt Lake City, Utah, 84143
    • McKay-Dee Hospital Center, Ogden, Utah, 84403
    • Logan Regional Hospital, Logan, Utah, 84321
  • Arizona

    • Arizona Oncology-Deer Valley Center, Phoenix, Arizona, 85027
    • Arizona Breast Cancer Specialists, Scottsdale, Arizona, 85251
    • Arizona Breast Cancer Specialists, Scottsdale, Arizona, 85251
    • Pinnacle Oncology Hematology, Scottsdale, Arizona, 85258
    • Pinnacle Oncology Hematology, Scottsdale, Arizona, 85258
    • Arizona Breast Cancer Specialists-Scottsdale, Scottsdale, Arizona, 85258
    • Arizona Breast Cancer Specialists-Scottsdale, Scottsdale, Arizona, 85258
    • Arizona Oncology Services Foundation, Scottsdale, Arizona, 85260
  • Oregon

    • Providence Medford Medical Center, Medford, Oregon, 97504
    • Asante Health System, Medford, Oregon, 97504
    • Rogue Valley Medical Center, Medford, Oregon, 97504
    • Asante Health System, Medford, Oregon, 97504
    • Three Rivers Community Hospital, Grants Pass, Oregon, 97527
    • Mid-Columbia Medical Center, The Dalles, Oregon, 97058
    • Mid-Columbia Medical Center, The Dalles, Oregon, 97058
    • Legacy Meridian Park Hospital, Tualatin, Oregon, 97062
    • Legacy Mount Hood Medical Center, Gresham, Oregon, 97030
    • Western Oncology Research Consortium, Portland, Oregon, 97213
    • Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, 97210
    • Legacy Emanuel Hospital and Health Center, Portland, Oregon, 97227
    • Compass Oncology Rose Quarter, Portland, Oregon, 97227
    • Kaiser Permanente, Portland, Oregon, 97227
    • Kaiser Permanente, Portland, Oregon, 97227
  • Colorado

    • Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, 81502
    • Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, 81502
    • Valley View Hospital Cancer Center, Glenwood Springs, Colorado, 81601
    • San Luis Valley Regional Medical Center, Alamosa, Colorado, 81101
    • The Shaw Regional Cancer Center, Edwards, Colorado, 81632
    • Memorial Hospital Colorado Springs, Colorado Springs, Colorado, 80909
    • Memorial Hospital Colorado Springs, Colorado Springs, Colorado, 80909
    • Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado, 80120
    • Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado, 80120
    • Boulder Community Hospital, Boulder, Colorado, 80301
    • Denver Health Medical Center, Denver, Colorado, 80204
    • Denver Health Medical Center, Denver, Colorado, 80204
    • Kaiser Permanente-Lone Tree, Lone Tree, Colorado, 80124
    • Kaiser Permanente-Franklin, Denver, Colorado, 80205
    • Kaiser Permanente-Rock Creek, Lafayette, Colorado, 80026
    • Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado, 80260
    • Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado, 80012
    • University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora, Colorado, 80045
  • New Mexico

    • Hematology Oncology Associates, Albuquerque, New Mexico, 87106
    • University of New Mexico, Albuquerque, New Mexico, 87106
    • Hematology Oncology Associates, Albuquerque, New Mexico, 87106
    • Memorial Medical Center - Las Cruces, Las Cruces, New Mexico, 88011
  • Washington

    • Providence Saint Mary Regional Cancer Center, Walla Walla, Washington, 99362
    • Providence Saint Mary Regional Cancer Center, Walla Walla, Washington, 99362
    • Compass Oncology Vancouver, Vancouver, Washington, 98684
    • Compass Oncology Vancouver, Vancouver, Washington, 98684
    • Legacy Salmon Creek Hospital, Vancouver, Washington, 98686
    • Tri-Cities Cancer Center, Kennewick, Washington, 99336
    • Saint John Medical Center, Longview, Washington, 98632
    • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington, 98902
    • Providence Regional Cancer System-Centralia, Centralia, Washington, 98531
    • Providence Regional Cancer System-Centralia, Centralia, Washington, 98531
    • Multicare Health System, Tacoma, Washington, 98415
    • Multicare Health System, Tacoma, Washington, 98415
    • Capital Medical Center, Olympia, Washington, 98507
    • Providence Regional Cancer System-Lacey, Lacey, Washington, 98503
    • Providence Regional Cancer System-Lacey, Lacey, Washington, 98503
    • Saint Elizabeth Hospital, Enumclaw, Washington, 98022
    • MultiCare Good Samaritan Hospital, Puyallup, Washington, 98372
    • Good Samaritan Community Hospital, Puyallup, Washington, 98372
    • Saint Clare Hospital, Lakewood, Washington, 98499
    • Saint Clare Hospital, Lakewood, Washington, 98499
    • Franciscan Research Center-Northwest Medical Plaza, Tacoma, Washington, 98405
    • Saint Joseph Medical Center, Tacoma, Washington, 98405
    • Northwest Medical Specialties PLLC, Tacoma, Washington, 98405
    • Northwest CCOP, Tacoma, Washington, 98405
    • MultiCare Allenmore Hospital, Tacoma, Washington, 98405
    • Northwest Medical Specialties PLLC, Tacoma, Washington, 98405
    • Auburn Regional Medical Center, Auburn, Washington, 98001
    • Auburn Regional Medical Center, Auburn, Washington, 98001
    • Rockwood Cancer Treatment Center-DHEC-Downtown, Spokane, Washington, 99204
    • Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, 99204
    • Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, 99204
    • Rockwood Cancer Treatment Center-DHEC-Downtown, Spokane, Washington, 99204
    • Cancer Care Northwest-Valley, Spokane, Washington, 99216
    • Rockwood Clinic Cancer Treatment Center-Valley, Spokane Valley, Washington, 99216
    • Cancer Care Northwest-Valley, Spokane, Washington, 99216
    • Rockwood Clinic Cancer Treatment Center-Valley, Spokane Valley, Washington, 99216
    • Cancer Care Northwest-North Spokane, Spokane, Washington, 99218
    • Valley Medical Center, Renton, Washington, 98055
    • Valley Medical Center, Renton, Washington, 98055
    • Olympic Medical Cancer Care Center, Sequim, Washington, 98384
    • Overlake Internal Medicine Associates, Bellevue, Washington, 98004
    • Overlake Internal Medicine Associates, Bellevue, Washington, 98004
    • Overlake Hospital Medical Center, Bellevue, Washington, 98004
    • Pacific Medical Center-First Hill, Seattle, Washington, 98104
    • Virginia Mason Medical Center, Seattle, Washington, 98101
    • Virginia Mason CCOP, Seattle, Washington, 98101
    • Group Health, Seattle, Washington, 98109
    • EvergreenHealth Medical Center, Kirkland, Washington, 98033
    • EvergreenHealth Medical Center, Kirkland, Washington, 98033
    • Providence Regional Cancer Partnership, Everett, Washington, 98201
    • Olympic Medical Center, Port Angeles, Washington, 98362
    • Olympic Medical Center, Port Angeles, Washington, 98362
    • Skagit Valley Hospital Regional Cancer Care Center, Mount Vernon, Washington, 98273
    • Skagit Valley Hospital Regional Cancer Care Center, Mount Vernon, Washington, 98273
  • Idaho

    • Saint Joseph Regional Medical Center, Lewiston, Idaho, 83501
    • Saint Joseph Regional Medical Center, Lewiston, Idaho, 83501
  • Wyoming

    • Cheyenne Regional Medical Center-West, Cheyenne, Wyoming, 82001
  • Montana

    • Guardian Oncology and Center for Wellness, Missoula, Montana, 59804
    • Guardian Oncology and Center for Wellness, Missoula, Montana, 59804
    • Community Medical Hospital, Missoula, Montana, 59801
    • Community Medical Hospital, Missoula, Montana, 59801
    • Northern Rockies Radiation Oncology Center, Billings, Montana, 59101
    • Northern Rockies Radiation Oncology Center, Billings, Montana, 59101
    • Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, 59405
    • Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, 59405
    • Kalispell Medical Oncology, Kalispell, Montana, 59901
  • Texas

    • West Texas Cancer Center, Odessa, Texas, 79761
    • The Don and Sybil Harrington Cancer Center, Amarillo, Texas, 79106
    • Covenant Medical Center-Lakeside, Lubbock, Texas, 79410
    • University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229
    • Doctor's Hospital of Laredo, Laredo, Texas, 78041
    • Texas Oncology-Grapevine, Grapevine, Texas, 76053
    • Texas Oncology-Grapevine, Grapevine, Texas, 76053
    • Texas Oncology Bedford, Bedford, Texas, 76022
    • Texas Oncology-Flower Mound, Flower Mound, Texas, 75028
    • Texas Oncology-Flower Mound, Flower Mound, Texas, 75028
    • Texas Oncology-Arlington South, Arlington, Texas, 76014
    • Texas Oncology - Central Austin Cancer Center, Austin, Texas, 78731
    • Texas Oncology - Lewisville, Lewisville, Texas, 75067
    • Scott and White Memorial Hospital, Temple, Texas, 76508
    • Scott and White Memorial Hospital, Temple, Texas, 76508
    • University Medical Center Brackenridge, Austin, Texas, 78701
    • University Medical Center Brackenridge, Austin, Texas, 78701
    • Austin Cancer Centers-Central Austin, Austin, Texas, 78702
    • Austin Cancer Centers-Central Austin, Austin, Texas, 78702
    • Texas Oncology-Plano West, Plano, Texas, 75093
    • Parkland Memorial Hospital, Dallas, Texas, 75235
    • Parkland Memorial Hospital, Dallas, Texas, 75235
    • Texas Oncology Methodist Charlton Cancer Center, Dallas, Texas, 75237
    • Texas Oncology Methodist Charlton Cancer Center, Dallas, Texas, 75237
    • Texas Cancer Center - Medical City Dallas, Dallas, Texas, 75230
    • Texas Cancer Center - Medical City Dallas, Dallas, Texas, 75230
    • Texas Oncology at Baylor Charles A Sammons Cancer Center, Dallas, Texas, 75246
    • Texas Oncology at Baylor Charles A Sammons Cancer Center, Dallas, Texas, 75246
    • University of Texas Southwestern Medical Center, Dallas, Texas, 75390
    • Tyler Cancer Center, Tyler, Texas, 75702
    • Tyler Cancer Center, Tyler, Texas, 75702
    • Texas Oncology-Longview Cancer Center, Longview, Texas, 75601
    • Texas Oncology-Longview Cancer Center, Longview, Texas, 75601
    • Memorial Hermann Memorial City Medical Center, Houston, Texas, 77024
    • Methodist Hospital, Houston, Texas, 77030
    • Baylor College of Medicine, Houston, Texas, 77030
  • Nebraska

    • Regional West Medical Center, Scottsbluff, Nebraska, 69361
    • Regional West Medical Center, Scottsbluff, Nebraska, 69361
    • Great Plains Regional Medical Center, North Platte, Nebraska, 69103
    • Great Plains Regional Medical Center, North Platte, Nebraska, 69103
    • Heartland Hematology and Oncology, Kearney, Nebraska, 68845
    • Saint Francis Medical Center, Grand Island, Nebraska, 68803
    • Saint Francis Medical Center, Grand Island, Nebraska, 68803
    • Faith Regional Medical Offices West, Norfolk, Nebraska, 68701
    • Faith Regional Medical Offices West, Norfolk, Nebraska, 68701
    • Southeast Nebraska Hematology and Oncology Consultants, P.C, Lincoln, Nebraska, 68510
    • Saint Elizabeth Regional Medical Center, Lincoln, Nebraska, 68510
    • Nebraska Hematology and Oncology, Lincoln, Nebraska, 68506
    • Nebraska Hematology and Oncology, Lincoln, Nebraska, 68506
    • Alegent Health Lakeside Hospital, Omaha, Nebraska, 68130
    • Oncology Hematology West PC, Omaha, Nebraska, 68130
    • Urology Cancer Center PC, Omaha, Nebraska, 68130
    • Urology Cancer Center PC, Omaha, Nebraska, 68130
    • Oncology Hematology West PC, Omaha, Nebraska, 68130
    • University of Nebraska Medical Center, Omaha, Nebraska, 68198
    • Midlands Community Hospital, Papillion, Nebraska, 68046
    • Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, 68124
    • Oncology Hematology West, Omaha, Nebraska, 68124
    • Oncology Hematology West, Omaha, Nebraska, 68124
    • Nebraska Methodist Hospital, Omaha, Nebraska, 68114
    • Alegent Health Immanuel Medical Center, Omaha, Nebraska, 68122
    • Hemotology and Oncology Consultants PC, Omaha, Nebraska, 68122
    • Missouri Valley Cancer Consortium, Omaha, Nebraska, 68106
    • Creighton University Medical Center, Omaha, Nebraska, 68131
  • Kansas

    • Saint Catherine Hospital, Garden City, Kansas, 67846
    • Wesley Medical Center, Wichita, Kansas, 67214
    • Wesley Medical Center, Wichita, Kansas, 67214
    • Newman Regional Health, Emporia, Kansas, 66801
    • Shawnee Mission Medical Center, Shawnee Mission, Kansas, 66204
    • Shawnee Mission Medical Center, Shawnee Mission, Kansas, 66204
  • Oklahoma

    • Cancer Centers of Southwest Oklahoma Research, Lawton, Oklahoma, 73505
    • Integris Cancer Institute of Oklahoma, Oklahoma City, Oklahoma, 73142
    • Integris Cancer Institute of Oklahoma, Oklahoma City, Oklahoma, 73142
    • Cancer Care Associates-Mercy, Oklahoma City, Oklahoma, 73120
    • Mercy Physicians of Oklahoma-Lakeside, Oklahoma City, Oklahoma, 73120
    • Mercy Physicians of Oklahoma-Lakeside, Oklahoma City, Oklahoma, 73120
    • Integris Southwest Medical Center, Oklahoma City, Oklahoma, 73109
    • Integris Southwest Medical Center, Oklahoma City, Oklahoma, 73109
    • University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104
    • Cancer Care Associates-Norman, Norman, Oklahoma, 73071
    • Saint John Medical Center, Tulsa, Oklahoma, 74104
    • Saint John Medical Center, Tulsa, Oklahoma, 74104
    • Surgical Associates Inc, Tulsa, Oklahoma, 74136
    • Surgical Associates Inc, Tulsa, Oklahoma, 74136
  • North Dakota

    • Bismarck Cancer Center, Bismarck, North Dakota, 58501
    • Bismarck Cancer Center, Bismarck, North Dakota, 58501
    • Trinity Cancer Care Center, Minot, North Dakota, 58701
  • South Dakota

    • Conklin Regional Cancer Center, Aberdeen, South Dakota, 57401
    • Conklin Regional Cancer Center, Aberdeen, South Dakota, 57401
    • Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, 57105
    • Medical X-Ray Center, Sioux Falls, South Dakota, 57105
    • Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, 57105
    • Medical X-Ray Center, Sioux Falls, South Dakota, 57105
    • Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota, 57104
  • Iowa

    • Alegent Health Mercy Hospital, Council Bluffs, Iowa, 51503
    • McFarland Clinic PC-Jefferson, Jefferson, Iowa, 50129
    • McFarland Clinic PC-Trinity Cancer Center, Fort Dodge, Iowa, 50501
    • Mercy Medical Center-West Lakes, West Des Moines, Iowa, 50266
    • Mercy Medical Center-West Lakes, West Des Moines, Iowa, 50266
    • Medical Oncology and Hematology Associates-West Des Moines, Clive, Iowa, 50325
    • Medical Oncology and Hematology Associates-West Des Moines, Clive, Iowa, 50325
    • Mercy Cancer Center-West Lakes, Clive, Iowa, 50325
    • McFarland Clinic PC-Boone, Boone, Iowa, 50036
    • Medical Oncology and Hematology Associates-Laurel, Des Moines, Iowa, 50314
    • Medical Oncology and Hematology Associates-Laurel, Des Moines, Iowa, 50314
    • Mercy Medical Center - Des Moines, Des Moines, Iowa, 50314
    • Medical Oncology and Hematology Associates-Des Moines, Des Moines, Iowa, 50309
    • Iowa Oncology Research Association CCOP, Des Moines, Iowa, 50309
    • Iowa Lutheran Hospital, Des Moines, Iowa, 50316
    • Mercy Capitol, Des Moines, Iowa, 50307
    • Mercy Capitol, Des Moines, Iowa, 50307
    • Mary Greeley Medical Center, Ames, Iowa, 50010
    • McFarland Clinic PC-Marshalltown, Marshalltown, Iowa, 50158
    • Mercy Medical Center - North Iowa, Mason City, Iowa, 50401
    • Ottumwa Regional Health Center, Ottumwa, Iowa, 52501
    • Ottumwa Regional Health Center, Ottumwa, Iowa, 52501
    • Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa, 52402
    • Saint Luke's Hospital, Cedar Rapids, Iowa, 52402
    • Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa, 52402
    • Saint Luke's Hospital, Cedar Rapids, Iowa, 52402
    • Cedar Rapids Oncology Association, Cedar Rapids, Iowa, 52403
    • Mercy Hospital, Cedar Rapids, Iowa, 52403
    • Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa, 52403
    • Mercy Hospital, Cedar Rapids, Iowa, 52403
    • Hematology Oncology Associates-Quad Cities, Bettendorf, Iowa, 52722
    • Constantinou, Costas L MD (UIA Investigator), Bettendorf, Iowa, 52722
  • Missouri

    • Mercy Hospital-Joplin, Joplin, Missouri, 64804
    • Freeman Health System, Joplin, Missouri, 64804
    • Freeman Health System, Joplin, Missouri, 64804
    • Mercy Hospital-Joplin, Joplin, Missouri, 64804
    • Saint Joseph Health Center, Kansas City, Missouri, 64114
    • Liberty Radiation Oncology Center, Liberty, Missouri, 64068
    • Liberty Hospital, Liberty, Missouri, 64068
    • Central Care Cancer Center-Carrie J Babb Cancer Center, Bolivar, Missouri, 65613
    • Central Care Cancer Center-Carrie J Babb Cancer Center, Bolivar, Missouri, 65613
    • CoxHealth Cancer Center, Branson, Missouri, 65616
    • CoxHealth Cancer Center, Branson, Missouri, 65616
    • University of Missouri - Ellis Fischel, Columbia, Missouri, 65212
    • Capital Region Medical Center-Goldschmidt Cancer Center, Jefferson City, Missouri, 65109
    • Missouri Baptist Sullivan Hospital, Sullivan, Missouri, 63080
    • Missouri Baptist Sullivan Hospital, Sullivan, Missouri, 63080
    • Siteman Cancer Center - Saint Peters, Saint Peters, Missouri, 63376
    • Parkland Health Center-Bonne Terre, Bonne Terre, Missouri, 63628
    • Parkland Health Center-Bonne Terre, Bonne Terre, Missouri, 63628
    • Center for Cancer Care and Research, Saint Louis, Missouri, 63141
    • Comprehensive Cancer Care PC, Saint Louis, Missouri, 63141
    • Barnes-Jewish West County Hospital, Saint Louis, Missouri, 63141
    • Center for Cancer Care and Research, Saint Louis, Missouri, 63141
    • Missouri Baptist Medical Center, Saint Louis, Missouri, 63131
    • Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills, Missouri, 63127
    • Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills, Missouri, 63127
    • Saint Anthony's Medical Center, Saint Louis, Missouri, 63128
    • Saint Anthony's Medical Center, Saint Louis, Missouri, 63128
    • Saint Louis University Hospital, Saint Louis, Missouri, 63110
    • Washington University School of Medicine, Saint Louis, Missouri, 63110
    • Christian Hospital Northeast - Northwest, Saint Louis, Missouri, 63136
    • Christian Hospital Northeast - Northwest, Saint Louis, Missouri, 63136
    • Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, 63670
    • Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri, 63670
    • Southeast Missouri Hospital, Cape Girardeau, Missouri, 63701
    • Southeast Missouri Hospital, Cape Girardeau, Missouri, 63701
    • Southeast Cancer Center, Cape Girardeau, Missouri, 63703
  • Arkansas

    • Saint Edward Mercy Medical Center, Ft. Smith, Arkansas, 72903
  • Minnesota

    • Lake Region Healthcare Corporation-Cancer Care, Fergus Falls, Minnesota, 56537
    • Lake Region Healthcare Corporation-Cancer Care, Fergus Falls, Minnesota, 56537
    • Rice Memorial Hospital, Willmar, Minnesota, 56201
    • New Ulm Medical Center, New Ulm, Minnesota, 56073
    • Hutchinson Area Health Care, Hutchinson, Minnesota, 55350
    • Saint Francis Regional Medical Center, Shakopee, Minnesota, 55379
    • Fairview Ridges Hospital, Burnsville, Minnesota, 55337
    • Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, 55416
    • North Memorial Medical Health Center, Robbinsdale, Minnesota, 55422
    • Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota, 56401
    • Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota, 56401
    • Hennepin County Medical Center, Minneapolis, Minnesota, 55415
    • Health Partners Inc, Minneapolis, Minnesota, 55454
    • Health Partners Inc, Minneapolis, Minnesota, 55454
    • Mercy Hospital, Coon Rapids, Minnesota, 55433
    • Unity Hospital, Fridley, Minnesota, 55432
    • Regions Hospital, Saint Paul, Minnesota, 55101
    • Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, 55109
    • Saint John's Hospital - Healtheast, Maplewood, Minnesota, 55109
    • Minnesota Oncology and Hematology PA-Woodbury, Woodbury, Minnesota, 55125
    • Lakeview Hospital, Stillwater, Minnesota, 55082
    • Saint Luke's Hospital of Duluth, Duluth, Minnesota, 55805
    • Miller-Dwan Hospital, Duluth, Minnesota, 55805
    • Essentia Health Saint Mary's Medical Center, Duluth, Minnesota, 55805
  • Illinois

    • Memorial Hospital, Carthage, Illinois, 62321
    • Mcdonough District Hospital, Macomb, Illinois, 61455
    • Holy Family Medical Center, Monmouth, Illinois, 61462
    • Saint Anthony's Health, Alton, Illinois, 62002
    • Garneau, Stewart C MD (UIA Investigator), Moline, Illinois, 61265
    • Porubcin, Michael MD (UIA Investigator), Moline, Illinois, 61265
    • Spector, David MD (UIA Investigator), Moline, Illinois, 61265
    • Western Illinois Cancer Treatment Center, Galesburg, Illinois, 61401
    • Galesburg Cottage Hospital, Galesburg, Illinois, 61401
    • Western Illinois Cancer Treatment Center, Galesburg, Illinois, 61401
    • Galesburg Cottage Hospital, Galesburg, Illinois, 61401
    • Mason District Hospital, Havana, Illinois, 62644
    • Graham Hospital Association, Canton, Illinois, 61520
    • Pekin Cancer Treatment Center, Pekin, Illinois, 61554
    • Pekin Hospital, Pekin, Illinois, 61554
    • Pekin Hospital, Pekin, Illinois, 61554
    • Proctor Hospital, Peoria, Illinois, 61614
    • Methodist Medical Center of Illinois, Peoria, Illinois, 61603
    • Hopedale Medical Complex - Hospital, Hopedale, Illinois, 61747
    • Hopedale Medical Complex - Hospital, Hopedale, Illinois, 61747
    • Perry Memorial Hospital, Princeton, Illinois, 61356
    • Eureka Hospital, Eureka, Illinois, 61530
    • Saint Margaret's Hospital, Spring Valley, Illinois, 61362
    • Illinois CancerCare-Spring Valley, Spring Valley, Illinois, 61362
    • Saint Margaret's Hospital, Spring Valley, Illinois, 61362
    • Saint Joseph Medical Center, Bloomington, Illinois, 61701
    • Valley Radiation Oncology, Peru, Illinois, 61354
    • Illinois Valley Hospital, Peru, Illinois, 61354
    • Valley Radiation Oncology, Peru, Illinois, 61354
    • Mid-Illinois Hematology Oncology Associates, Normal, Illinois, 61761
    • Bromenn Regional Medical Center, Normal, Illinois, 61761
    • Mid-Illinois Hematology Oncology Associates, Normal, Illinois, 61761
    • Radiation Oncology of Northern Illinois, Ottawa, Illinois, 61350
    • Radiation Oncology of Northern Illinois, Ottawa, Illinois, 61350
    • Ottawa Regional Hospital and Healthcare Center, Ottawa, Illinois, 61350
    • Carle Physician Group-Effingham, Effingham, Illinois, 62401
    • Carle Physician Group-Effingham, Effingham, Illinois, 62401
    • Saint Anthony Medical Center, Rockford, Illinois, 61108
    • Saint Anthony Medical Center, Rockford, Illinois, 61108
    • Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, 61938
    • Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, 61938
    • Rush-Copley Healthcare Center, Yorkville, Illinois, 60560
    • Rush-Copley Healthcare Center, Yorkville, Illinois, 60560
    • The Carle Foundation Hospital, Urbana, Illinois, 61801
    • Carle Cancer Center, Urbana, Illinois, 61801
    • Carle Clinic-Urbana Main, Urbana, Illinois, 61801
    • The Carle Foundation Hospital, Urbana, Illinois, 61801
    • Rush - Copley Medical Center, Aurora, Illinois, 60504
    • Cadence Cancer Center in Warrenville, Warrenville, Illinois, 60555
    • Joliet Oncology-Hematology Associates Limited, Joliet, Illinois, 60435
    • Edward Hospital/Cancer Center, Naperville, Illinois, 60540
    • Edward Hospital/Cancer Center, Naperville, Illinois, 60540
    • Midwest Center for Hematology Oncology, Joliet, Illinois, 60432
    • Midwest Center for Hematology Oncology, Joliet, Illinois, 60432
    • Presence Saint Mary's Hospital, Kankakee, Illinois, 60901
    • Alexian Brothers Medical and Cancer Center, Elk Grove Village, Illinois, 60007
    • Alexian Brothers Medical and Cancer Center, Elk Grove Village, Illinois, 60007
    • Elmhurst Memorial Hospital, Elmhurst, Illinois, 60126
    • Elmhurst Memorial Hospital, Elmhurst, Illinois, 60126
    • Adventist La Grange Memorial Hospital, La Grange, Illinois, 60525
    • Carle on Vermilion, Danville, Illinois, 61832
    • Carle on Vermilion, Danville, Illinois, 61832
    • North Shore Hematology Oncology, Libertyville, Illinois, 60048
    • Loyola University Medical Center, Maywood, Illinois, 60153
    • West Suburban Medical Center, River Forest, Illinois, 60305
    • Mac Neal Hospital, Berwyn, Illinois, 60402
    • Mac Neal Hospital, Berwyn, Illinois, 60402
    • Resurrection Healthcare, Chicago, Illinois, 60631
    • Resurrection Healthcare, Chicago, Illinois, 60631
    • Illinois Cancer Specialists-Niles, Niles, Illinois, 60714
    • Hematology Oncology Associates of Illinois-Highland Park, Highland Park, Illinois, 60035
    • Ingalls Memorial Hospital, Harvey, Illinois, 60426
    • Hematology Oncology Associates of Illinois - Skokie, Skokie, Illinois, 60076
    • University of Illinois, Chicago, Illinois, 60612
    • Rush University Medical Center, Chicago, Illinois, 60612
    • Swedish Covenant Hospital, Chicago, Illinois, 60625
    • Swedish Covenant Hospital, Chicago, Illinois, 60625
    • Mount Sinai Hospital Medical Center, Chicago, Illinois, 60608
    • Mount Sinai Hospital Medical Center, Chicago, Illinois, 60608
    • Saint Francis Hospital, Evanston, Illinois, 60202
    • Saint Francis Hospital, Evanston, Illinois, 60202
    • Saint Joseph Hospital, Chicago, Illinois, 60657
    • Saint Joseph Hospital, Chicago, Illinois, 60657
    • Advocate Illinois Masonic Medical Center, Chicago, Illinois, 60657
    • Northwestern University, Chicago, Illinois, 60611
  • Wisconsin

    • Cancer Center of Western Wisconsin, New Richmond, Wisconsin, 54017
    • Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, 54601
    • Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire, Wisconsin, 54701
    • Marshfield Clinic-Rice Lake Center, Rice Lake, Wisconsin, 54868
    • Marshfield Clinic-Chippewa Center, Chippewa Falls, Wisconsin, 54729
    • Marshfield Clinic, Marshfield, Wisconsin, 54449
    • Dean Hematology and Oncology Clinic, Madison, Wisconsin, 53717
    • University of Wisconsin Hospital and Clinics, Madison, Wisconsin, 53792
    • Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, 54494
    • Mercy Health System, Janesville, Wisconsin, 53547
    • Saint Michael's Hospital, Stevens Point, Wisconsin, 54481
    • Marshfield Clinic Cancer Care at Saint Michael's Hospital, Stevens Point, Wisconsin, 54481
    • Aspirus Regional Cancer Center, Wausau, Wisconsin, 54401
    • UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin, 53038
    • Aurora Cancer Care-Southern Lakes, Elkhorn, Wisconsin, 53121
    • Aurora Cancer Care-Southern Lakes, Elkhorn, Wisconsin, 53121
    • Aurora Medical Center in Summit, Summit, Wisconsin, 53066
    • Marshfield Clinic at James Beck Cancer Center, Rhinelander, Wisconsin, 54501
    • Langlade Hospital and Cancer Center, Antigo, Wisconsin, 54409
    • D N Greenwald Center, Mukwonago, Wisconsin, 53149
    • Aurora Cancer Care-Burlington, Burlington, Wisconsin, 53105
    • Aurora Cancer Care-Burlington, Burlington, Wisconsin, 53105
    • Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, 54904
    • Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, 54904
    • Aurora Cancer Care-Waukesha, Waukesha, Wisconsin, 53188
    • Waukesha Memorial Hospital - ProHealth Care, Waukesha, Wisconsin, 53188
    • Aurora Cancer Care-Waukesha, Waukesha, Wisconsin, 53188
    • Agnesian Cancer Center, Fond Du Lac, Wisconsin, 54935
    • Community Memorial Hospital, Menomonee Falls, Wisconsin, 53051
    • Aurora Advanced Healthcare Inc-Menomonee Falls, Menomonee Falls, Wisconsin, 53051
    • Aurora Advanced Healthcare Inc-Menomonee Falls, Menomonee Falls, Wisconsin, 53051
    • The Alyce and Elmore Kraemer Cancer Care Center, West Bend, Wisconsin, 53095
    • The Alyce and Elmore Kraemer Cancer Care Center, West Bend, Wisconsin, 53095
    • Aurora West Allis Medical Center, West Allis, Wisconsin, 53227
    • Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin, 53226
    • Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, 53226
    • Fox Valley Surgical Associates Limited, Appleton, Wisconsin, 54911
    • Appleton Medical Center, Appleton, Wisconsin, 54911
    • Fox Valley Surgical Associates Limited, Appleton, Wisconsin, 54911
    • Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, 53142
    • Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, 53142
    • Wheaton Franciscan Healthcare - Saint Joseph, Milwaukee, Wisconsin, 53210
    • Wheaton Franciscan Healthcare - Saint Joseph, Milwaukee, Wisconsin, 53210
    • Columbia Saint Mary's Hospital - Ozaukee, Mequon, Wisconsin, 53097
    • Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, 53215
    • Aurora Cancer Care-Milwaukee South, Milwaukee, Wisconsin, 53215
    • Aurora Cancer Care-Milwaukee South, Milwaukee, Wisconsin, 53215
    • Aurora Sinai Medical Center, Milwaukee, Wisconsin, 53233
    • Aurora Sinai Medical Center, Milwaukee, Wisconsin, 53233
    • Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin, 53209
    • Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin, 53209
    • Columbia Saint Mary's Water Tower Medical Commons, Milwaukee, Wisconsin, 53211
    • Aurora Cancer Care-Grafton, Grafton, Wisconsin, 53024
    • Aurora Cancer Care-Grafton, Grafton, Wisconsin, 53024
    • Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin, 53081
    • Saint Nicholas Hospital, Sheboygan, Wisconsin, 53081
    • Holy Family Memorial Hospital, Manitowoc, Wisconsin, 54221
    • Vince Lombardi Cancer Clinic, Two Rivers, Wisconsin, 54241
    • Vince Lombardi Cancer Clinic-Marinette, Marinette, Wisconsin, 54143
  • Louisiana

    • Baton Rouge General Medical Center, Baton Rouge, Louisiana, 70806
    • Baton Rouge General Medical Center, Baton Rouge, Louisiana, 70806
    • Hematology/Oncology Clinic LLP, Baton Rouge, Louisiana, 70809
    • Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, 70809
    • Ochsner Health Center-Summa, Baton Rouge, Louisiana, 70809
    • Ochsner Health Center-Covington, Covington, Louisiana, 70433
    • Ochsner Health Center-Covington, Covington, Louisiana, 70433
    • Ochsner Medical Center Kenner, Kenner, Louisiana, 70065
    • Ochsner Medical Center Kenner, Kenner, Louisiana, 70065
    • Robert Veith MD LLC, Metairie, Louisiana, 70006
    • Robert Veith MD LLC, Metairie, Louisiana, 70006
    • Ochsner Medical Center Jefferson, New Orleans, Louisiana, 70121
    • Ochsner Baptist Medical Center, New Orleans, Louisiana, 70115
    • West Jefferson Medical Center, Marrero, Louisiana, 70072
    • Tulane University Health Sciences Center, New Orleans, Louisiana, 70112
    • Louisiana State University Health Science Center, New Orleans, Louisiana, 70112
    • Interim LSU Public Hospital, New Orleans, Louisiana, 70112
    • Interim LSU Public Hospital, New Orleans, Louisiana, 70112
  • Mississippi

    • University of Mississippi Medical Center, Jackson, Mississippi, 39216
    • Hattiesburg Clinic, Hattiesburg, Mississippi, 39401
    • Hattiesburg Clinic, Hattiesburg, Mississippi, 39401
    • Forest General Hospital, Hattiesburg, Mississippi, 39404
    • Forest General Hospital, Hattiesburg, Mississippi, 39404
    • Gulfport Memorial Hospital, Gulfport, Mississippi, 39502
    • Gulfport Memorial Hospital, Gulfport, Mississippi, 39502
  • Indiana

    • The Community Hospital, Munster, Indiana, 46321
    • The Community Hospital, Munster, Indiana, 46321
    • Michiana Hematology Oncology-PC Westville, Westville, Indiana, 46391
    • Franciscan Saint Anthony Health-Michigan City, Michigan City, Indiana, 46360
    • Woodland Cancer Care Center, Michigan City, Indiana, 46360
    • Woodland Cancer Care Center, Michigan City, Indiana, 46360
    • Saint Vincent Hospital and Health Services, Indianapolis, Indiana, 46260
    • Saint Vincent Hospital and Health Services, Indianapolis, Indiana, 46260
    • Michiana Hematology Oncology PC-Plymouth, Plymouth, Indiana, 46563
    • IU Health Methodist Hospital, Indianapolis, Indiana, 46202
    • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, 46202
    • Northern Indiana Cancer Research Consortium, South Bend, Indiana, 46628
    • Franciscan Saint Francis Health-Indianapolis, Indianapolis, Indiana, 46237
    • Michiana Hematology Oncology PC-South Bend, South Bend, Indiana, 46601
    • IU Health Central Indiana Cancer Centers-East, Indianapolis, Indiana, 46219
    • Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana, 46545
    • Saint Joseph Regional Medical Center-Mishawaka, Mishawaka, Indiana, 46545
    • Memorial Regional Cancer Center Day Road, Mishawaka, Indiana, 46544
    • Michiana Hematology Oncology PC-Elkhart, Elkhart, Indiana, 46514
  • Alabama

    • Gulf Coast MBCCOP, Mobile, Alabama, 36604
    • Gulf Coast MBCCOP, Mobile, Alabama, 36604
    • Northeast Alabama Regional Medical Center, Anniston, Alabama, 36202
    • Northeast Alabama Regional Medical Center, Anniston, Alabama, 36202
  • Tennessee

    • Meharry Medical College, Nashville, Tennessee, 37208
    • Meharry Medical College, Nashville, Tennessee, 37208
    • Memorial Hospital, Chattanooga, Tennessee, 37404
    • Pulmonary Medicine Center of Chattanooga-Hixson, Hixson, Tennessee, 37343
    • Memorial GYN Plus, Ooltewah, Tennessee, 37363
  • Michigan

    • Lakeland Hospital, St. Joseph, Michigan, 49085
    • Marie Yeager Cancer Center, Saint Joseph, Michigan, 49085
    • Lakeland Community Hospital, Niles, Michigan, 49120
    • Marquette General Hospital, Marquette, Michigan, 49855
    • Marquette General Hospital, Marquette, Michigan, 49855
    • McLaren-Greater Lansing, Lansing, Michigan, 48910
    • Mid-Michigan Medical Center - Midland, Midland, Michigan, 48670
    • Mid-Michigan Medical Center - Midland, Midland, Michigan, 48670
  • Kentucky

    • Hardin Memorial Hospital, Elizabethtown, Kentucky, 42701
    • Hardin Memorial Hospital, Elizabethtown, Kentucky, 42701
    • Saints Mary and Elizabeth Hospital, Louisville, Kentucky, 40215
    • Norton Hospital Pavilion and Medical Campus, Louisville, Kentucky, 40202
    • Norton Hospital Pavilion and Medical Campus, Louisville, Kentucky, 40202
    • Jewish Hospital Medical Center South, Shepherdsville, Kentucky, 40165
    • Baptist Health Louisville, Louisville, Kentucky, 40207
    • Baptist Health Louisville, Louisville, Kentucky, 40207
    • Jewish Hospital Medical Center Northeast, Louisville, Kentucky, 40245
    • Flaget Memorial Hospital, Bardstown, Kentucky, 40004
    • Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky, 40504
    • Baptist Health Lexington, Lexington, Kentucky, 40503
    • Baptist Health Lexington, Lexington, Kentucky, 40503
    • University of Kentucky, Lexington, Kentucky, 40536
    • Saint Joseph Hospital East, Lexington, Kentucky, 40509
  • Georgia

    • Harbin Clinic Medical Oncology and Clinical Research, Rome, Georgia, 30165
    • Harbin Clinic Medical Oncology and Clinical Research, Rome, Georgia, 30165
    • John B Amos Cancer Center, Columbus, Georgia, 31904
    • Well Star Cobb Hospital, Austell, Georgia, 30106
    • Well Star Cobb Hospital, Austell, Georgia, 30106
    • Wellstar Kennestone Hospital, Marietta, Georgia, 30060
    • Wellstar Kennestone Hospital, Marietta, Georgia, 30060
    • Piedmont Fayette Hospital, Fayetteville, Georgia, 30214
    • Atlanta Regional CCOP, Atlanta, Georgia, 30342
    • Atlanta Regional CCOP, Atlanta, Georgia, 30342
    • Northside Hospital, Atlanta, Georgia, 30342
    • Saint Joseph's Hospital of Atlanta, Atlanta, Georgia, 30342
    • Piedmont Hospital, Atlanta, Georgia, 30309
    • Southern Regional Medical Center, Riverdale, Georgia, 30274
    • Southern Regional Medical Center, Riverdale, Georgia, 30274
  • Ohio

    • TriHealth Cancer Institute-Westside, Cincinnati, Ohio, 45247
    • University of Cincinnati, Cincinnati, Ohio, 45267
    • University Pointe, West Chester, Ohio, 45069
    • University Pointe, West Chester, Ohio, 45069
    • TriHealth Cancer Institute-Anderson, Cincinnati, Ohio, 45255
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