Colorectal Cancer in Adolescents and Young Adults: A Pilot Study of Medical and Psychosocial Issues
Description
Brief Summary
This study investigates the medical and psychosocial consequences of colorectal cancer on
adolescents and young adults. Measuring physical function in adolescents and young adults
with colorectal cancer may help doctors better understand the level of physical function
during cancer treatment and how to improve the management of colorectal cancer in adolescents
and young adults. This study may also help design a future exercise program to decrease risk
factors including high blood pressure, high blood sugar, and high cholesterol.
Detailed Description
I. To prospectively characterize the symptom burden and assess the health-related quality of
life of adolescents and young adults (AYAs) in active treatment for colorectal cancer in
comparison to older patients to identify differences that contribute to the development of
appropriately timed, age appropriate interventions.
II. To characterize the symptom burden and assess the health-related quality of life of AYAs
who have completed curative therapy and are in surveillance for colorectal cancer compared to
older patients to identify differences that contribute to the development of appropriately
timed, age-appropriate interventions.
SECONDARY OBJECTIVE:
I. Using a prospective and cross-sectional design, characterize physical function, body
composition, and biomarkers of comorbid conditions among AYAs with colorectal cancer (CRC) on
active therapy and after completion of therapy in survivorship to identify targets for and
timing of interventions.
EXPLORATORY OBJECTIVE:
I. To assess across Aims differences by cancer site (colon versus [vs.] rectal) by sex, and
by race/ethnicity.
OUTLINE:
Patients on active treatment complete questionnaires and undergo collection of blood samples
and physical function assessments at baseline, and at 3 and 6 months. Survivors in
surveillance complete questionnaires and undergo collection of blood sample and physical
function assessment at baseline.
Phase
N/AInclusion and Exclusion Criteria
- Diagnosis of colorectal cancer (any stage)
- Any type of prior therapy
- Age >= 18-39 years for AYA/young adult sample, age 40+ for older comparison group
- For patients on active therapy: must have been diagnosed within the past three months. For survivors: must have completed curative therapy and are 6-24 months post-diagnosis
- Speak English or Spanish
- Ability to understand and the willingness to sign a written informed consent
- Patients who are more than 3 months from diagnosis, and survivors who are more than 24 months from initial diagnosis
- Patients who have a life expectancy of less than 6 months per their medical oncologist
- Patients who are deemed too ill or unable to participate by their medical oncologist (e.g., have cognitive impairment or brain metastases)
- Patients who do not speak English or Spanish
Sites
Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.
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