Novel Dynamic PET Kinetics and MRI Radiomics Analyses in Brain Tumors
Description
Brief Summary
This early phase I trial tests the use of a radioactive tracer (a drug that is visible during
an imaging test) known as 18F-FMAU, for imaging with positron emission tomography/computed
tomography (PET/CT) in patients with brain cancer or cancer that has spread to the brain
(brain metastases). A PET/CT scan is an imaging test that uses a small amount of radioactive
tracer (given through the vein) to take detailed pictures of areas inside the body where the
tracer is taken up. 18F-FMAU may also help find the cancer and how far the disease has
spread. Magnetic resonance imaging (MRI) is a type of imaging test used to diagnose brain
tumors. 18F-FMAU PET/CT in addition to MRI may make the finding and diagnosing of brain tumor
easier.
Detailed Description
I. Assess the correlation between multiparametric magnetic resonance imaging (mpMRI)
radiomics and dynamic 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU) PET kinetic
analysis parameters.
II. Explore the different pattern in radiomics mpMRI and FMAU PET kinetic analysis parameters
between patients with presence or absence of recurrent tumor.
OUTLINE:
Patients receive 18F-FMAU intravenously (IV) and undergo a PET/CT scan over 60 minutes.
Patients then undergo standard of care mpMRI over approximately 45 minutes.
After completion of study intervention, patients are followed up at 24-96 hours after their
18F-FMAU PET/CT scan.
Phase
N/AInclusion and Exclusion Criteria
- Age > 18 years, both men and women
- Documented history of either primary brain tumor (e.g. glioma) or metastatic brain tumor from another primary cancer (e.g. lung, breast, colon, melanoma, kidney)
- Documented radiation therapy regardless of treatments prior to radiation therapy
- Unable to give consent
- Inability to remain motionless during imaging studies
- Intractable seizures
- Claustrophobia
- Implantable devices incompatible with magnetic resonance (MR) environment
Sites
Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.
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