Screening Protocol to Assess the Expression of Tumor Associated Antigens (TAAs), Human Papillomavirus (HPV-16) Antigens and Human Leucocyte Antigen (HLA) Sub-Types in Patients With Head and Neck, Cervical, Melanoma and Non-Small Cell Lung Cancers.
Description
Brief Summary
The purpose of this study is to obtain archived tumor tissue or pre-existing antigen
expression data from patients with Head and Neck, Cervical, Melanoma and Non-Small Cell Lung
Cancers to assess antigen expression and patient suitability for a Repertoire Immune
Medicines Treatment Protocol.
Detailed Description
This screening study is intended for men and women at least 18 years of age who have selected
advanced solid tumors. The study will assess the patient's selected tumor antigens and/or
HPV-16 E6/E7 expression profiles. Human leukocyte antigen (HLA) subtype will also be
assessed.
Based on the results, it will be determined if a patient is eligible to be considered for a
Repertoire Immune Medicines sponsored clinical trial(s) testing of the safety and efficacy of
a multi-antigen cytokine-enhanced T cell therapy. No treatment intervention will occur as
part of this screening study.
Upon enrollment, patients will be required to provide archival tumor tissue and saliva
samples. Based upon the results of these diagnostic analyses, if eligible, patients may be
enrolled in an appropriate interventional clinical trial(s) at the discretion of the
Investigator.
Phase
N/AInclusion and Exclusion Criteria
- Be willing and able to provide written informed consent
- Age ≥ 18 years
- Histologically
- or cytologically-confirmed, relapsed/refractory, and metastatic or locally advanced head and neck, cervical, melanoma or non-small cell lung cancers. Other solid tumor types may be analyzed at the discretion of the Sponsor
- Able to provide archived tumor tissue or have existing data on TAAs, HPV status or HLA sub-type
- Willing to provide a saliva sample
- There are no exclusion criteria for this study.
Sites
Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.
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SC CTSI