CHLA Research Study on Childhood Outcomes of Preterm Brain Abnormalities

Purpose

The purpose of this CHLA Research Study is to collect and compare information from your child's magnetic resonance imaging (MRI) scans, neurological exam and neuropsychological assessments. We hope to find whether there is a specific pattern of brain changes associated with prematurity that will help with early screening, diagnosis, and treatment of brain injury in prematurely born children as well as identify a connection between MR imaging and neurodevelopmental outcomes.

Brain MRI must be done within months after birth.

Interested families whose baby does not have brain MRI can receive a scan paid for by the research study.

Participants can be recruited up to 12 years of age as long as they had the scan as a baby.

Participation in this study is voluntary.

Keywords: premature, mri, neurodevelopment, brain, magnetic resonance imaging, neuro, baby, child, infant

Study Sites

4650 W Sunset Blvd Los Angeles, CA 90027

 
  • Men & Women
Age icon
0 - 12
 
 
OR
 

What's involved?

Study length

  • Premie cohort - newborn - 18 months

  • 6-12 year old cohort - 1 day

Number of visits

  • Premie cohort - 3 visits

  • 6-12 year old cohort - 1 visit

Prescription
    None
Procedures

  • Brain MRI

  • Maternal Demographic Questionnaire

  • Neurodevelopment Exam

Compensation

  • Compensation is available for successful completion of study visits.

Medical cost coverage

  • Study-related tests and procedures are covered.

Eligibility

Must have

  • Brain MRI (within months after birth)
  • Preterm birth (GA 25-36 weeks)
  • English or Spanish speaking families

Procedures

Premie cohort - participation in this research cohort will last until your child is about 18 months of age. 

Visit 1: One time brain MRI, maternal demographic questionnaire

Visit 2: 9-12 month neurodevelopment exam

Visit 3: 18 months neurodevelopment exam

6 - 12 year old cohort- participation in this research cohort will last one day.

Visit 1: Neurodevelopment exam

  

Study Team

Photohandler
Principal Investigator
Natasha Lepore, PhD

For questions about this study, contact:

  • Clinical Research Coordinator Emy Dacalos
  • Children's Hospital Los Angeles
  • 323-361-7309
  • edacalos@chla.usc.edu
  • Clinical Research Coordinator Kayla Guzman
  • Children's Hospital Los Angeles
  • 323-361-6876
  • kayguzman@chla.usc.edu
  • IRB number: CHLA-19-00323
  • Study posted on: TBD
  • Recruitment period: 4/27/2021

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