Clinical Trials and Studies

Your participation matters. Help us discover and cure!

Contact us at (800) USC-CARE (800-872-2273)

We're sorry, but this trial is no longer enrolling volunteers.

A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Eculizumab in Subjects With Refractory Generalized Myasthenia Gravis (gMG)




Inclusion and Exclusion Criteria

  • - Male or female patients ≥18 years old - Diagnosis of MG made by the following tests:
  • Positive serologic test for anti-AChR Abs as confirmed at screening, and
  • One of the following:
  • History of abnormal neuromuscular transmission test demonstrated by single-fiber electromyography (SFEMG) or repetitive nerve stimulation, or
  • History of positive anticholinesterase test, e.g. edrophonium chloride test, or
  • Subject has demonstrated improvement in MG signs on oral cholinesterase inhibitors, as assessed by the treating physician. - MGFA Clinical Classification Class II to IV at screening. - MG-ADL total score must be ≥6 at screening. - Subjects who have:
  • Failed treatment with at least two immunosuppressive agents. Or,
  • Failed treatment with at least one immunosuppressive agent and require chronic plasma exchange or IVIg Key

  • History of thymoma or other neoplasms of the thymus
  • History of thymectomy within 12 months prior to screening
  • MGFA Class I or MG crisis at screening (MGFA Class V)
  • Use of rituximab within 6 months prior to screening
  • Use of IVIg or PE within 4 weeks prior to screening


Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.

Powered by SC CTSI