Early Onset and Familial Gastric Cancer Registry
Description
Brief Summary
The purpose of this study is to establish a gastric cancer registry. A registry is a
database of information. With the registry, we can learn more about the genetic causes of
gastric cancer in order to develop better methods of early diagnosis, prevention, and
treatment of gastric cancers. As part of this study, you will be asked to join a registry of
families who are affected with various forms of gastric cancer. These registries are
important because they may help physicians better manage gastric cancer now and in the
future. Participating in the Early Onset and Familial Gastric Cancer Registry can also be
educational for families, since it will provide important information to patients, families,
and physicians. All of this will help to further our understanding of genetic causes of
gastric cancer and eventually, help determine better ways to diagnose, treat, and survey
patients with gastric cancer and people who may have a higher risk for gastric cancer.
Phase
N/AInclusion and Exclusion Criteria
- Inclusion Criteria: Patient/Relative Cohort: Must meet one or more criteria below:
- A person with a diagnosis of gastric or gastroesophageal junction (GEJ) adenocarcinoma confirmed at the treating institution.
- A person without gastric or GEJ adenocarcinoma who has or had a first degree relative eligible for a High Risk Genetic sub-group (EOGC/FGC).
- Early Onset Gastric Cancer - diagnosis of gastric cancer before the age of 50 without a family history of the disease.
- Familial Gastric Cancer - having a family history of gastric cancer as defined as one first degree relative or 2 second degree relatives.
- A person without gastric or GEJ adenocarcinoma who has a personal family history of a genetic mutation associated with the development of gastric or GEJ adenocarcinoma (i.e. family history of CDH1 mutation). II. Must be willing to provide a blood sample for germline DNA. These individuals will sign the "Patient/Relative Consent". Following enrollment, we will assign individuals to the appropriate High Genetic Risk or Low Genetic Risk groups based on the age of diagnosis and their family history. Subject Exclusion Criteria Patients are ineligible for the study if they: - Have any condition, which in the opinion of the primary MSK clinician or investigators precludes their ability to provide informed consent. - Relatives of patients that are not eligible for the High Genetic Risk Cohorts who are less than 18 years of age are excluded. - Relatives of patients eligible for the High Genetic Risk Cohorts who do not have a proband available to join the study are excluded. (Unless there is a known CDH1 mutation in the family).
Sites
Please contact Judy Lam-Tran to learn more about where you can participate in this trial. Please use the contact form on the right side.
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