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Characterization of Mechanical Tissue Properties in Pancreas, Liver and Colon
This pilot research trial studies characterization of mechanical tissue properties in
patients with pancreatic, liver, or colon cancer. Mechanical properties and stiffness of the
cancerous tissue may be correlated with the standard pathology report that describes the
stage of the disease.
I. To determine if our optical polarimeter device is able to measure tissue stiffness across
several human cancer types ex vivo.
I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine
if the measurements made by the optical polarimeter device are non-destructive.
I. Perform multi-variable cross-correlation statistical analysis to determine relationships
between: tissue stiffness characteristics, molecular level signatures, and cellular level
properties, and if numbers permit, response to treatment.
Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue
samples are analyzed for tissue stiffness measurements using an optical polarimeter device
and cell viability using an automated cell counter.
Inclusion and Exclusion Criteria
- Scheduled for surgery to remove primary tumors in the pancreas, liver or colon and have not undergone any prior treatment
- Ability to understand and the willingness to sign a written informed consent
- Pregnant women will not be consented
- Patients that are unable to consent for surgery
- Primary liver tumors with cirrhosis will be excluded from this study
Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.