High-Intensity Interval Training (HIT) for Breast Cancer Patients During Trastuzumab Use
Description
Brief Summary
This randomized pilot clinical trial studies the feasibility of high-intensity interval
training in improving cardiovascular fitness in patients with stage I-III breast cancer
undergoing chemotherapy with trastuzumab. Trastuzumab helps patients live longer, but may
cause side effects to the heart. Aerobic exercise may help the heart function better, which
may help protect it against side effects from trastuzumab. Exercise may also help reduce
fatigue and prevent cancer from coming back. High-intensity interval training involves short
bursts of higher intensity efforts with longer periods of recovery. This may also allow
patients who cannot exercise for a long period of time to still be physically active. This
trial studies whether patients can tolerate high-intensity interval training, and how well it
works in improving fitness in patients with breast cancer receiving trastuzumab.
Detailed Description
I. To assess the feasibility (completion of > 80% exercise sessions) of utilizing
high-intensity interval training (HIT).
II. To determine the effects of HIT on aerobic exercise adaptation when compared to delayed
group.
III. To examine the effects of HIT on left ventricular function when compared to delayed
group.
IV. To determine the effects of HIT on endothelial function, arterial stiffness, and vascular
atherosclerosis when compared to delayed group.
OUTLINE: Participants are randomized to 1 of 2 groups.
ARM I: HIT (High-intensity Interval Training) group - Participants undergo HIT over 30
minutes, thrice weekly for 8 weeks.
ARM II: DEL (Delayed/usual care) group - Participants maintain their current sedentary
activity level (< 60 minutes of total exercise per week) for 8 weeks. Participants document
their weekly activity in an exercise log. Following completion of all study visits,
participants are given the option to complete the HIT exercise program as in Arm I.
After completion of study, patients are followed up at weeks 9 and 17.
Phase
N/AInclusion and Exclusion Criteria
- English or Spanish speaking
- Diagnosed with early stage (I-III) breast cancer, without evidence of metastatic disease
- Planned (neo)adjuvant therapy with trastuzumab (Herceptin) and/or anthracycline-based chemotherapy
- Not currently pregnant or planning to become pregnant throughout the duration of cancer treatment
- Physician (oncologist) clearance to participate in exercise at moderate to high intensity
- Have read and signed study informed consent document (ICF)
- EXERCISE INCLUSION CRITERIA:
- Normal body temperature (=< 100 degrees F)
- Resting blood pressure and/or heart rate within normal limits
- Participants have not received intravenous or oral chemotherapy on the same day and prior to scheduled exercise session Exclusion Criteria:
- Advanced stage (stage IV) or metastatic breast cancer diagnosis (screening for metastases with scans only needed if there is clinical suspicion for metastases)
- Medical history of coronary heart or artery disease, chronic or acute congestive heart failure or history of systolic or diastolic insufficiencies
- Uncontrolled hypertension or other uncontrolled chronic disease (e.g. diabetes mellitus, thyroid disease, pulmonary disease, etc.)
- Moderate to highly active level of physical activity (e.g. currently participating in >= 60 minutes of moderate aerobic activity weekly)
- Orthopedic or other restrictions or contraindications to high-intensity (cycling) exercise
- EXERCISE
- Presence of fever (>= 100 degrees F)
- Resting blood pressure and/or heart rate outside normal limits
- Participants have received intravenous or oral chemotherapy on the same day and prior to scheduled exercise session
Sites
Please contact the trial administrator to learn more about where you can participate in this trial. Please use the contact form on the right side.
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