Evaluation of Regional Gadolinium Retention in the Brain Using QSM With Correlation to Regional DCE MRI Permeability Using GOCART Technique in Intracranial Neoplasm Patients Receiving Gadobenate Dimeglumine (MultiHance) or Gadoterate Meglumine (Dotarem)
PRIMARY OBJECTIVES:
I. To obtain preliminary data (e.g. mean, variance, distribution) in the regional brain
parenchymal changes associated with gadolinium (Gd) deposition during 8 to 18 months period
after administration of gadolinium based contrast agents (GBCA) to Gd naive intracranial
neoplasm patients who will be randomized to gadobenate dimeglumine (MultiHance) or gadoterate
meglumine (Dotarem).
II. To explore if areas of increased regional Gd deposition at individual level are
correlated with baseline regional DCE permeability metrics such as volume transfer
coefficient reflecting vascular permeability (kTrans), extracellular volume ratio reflecting
vascular permeability (ve) and plasma volume (vp) in intracranial neoplasm patients.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients undergo standard of care QSM and T1 weighted imaging (T1WI). Patients then
receive gadobenate dimeglumine intravenously (IV) and undergo GOCART DCE MRI over 60 minutes.
ARM II: Patients undergo standard of care QSM and T1WI. Patients then receive gadoterate
meglumine IV and undergo GOCART DCE MRI over 60 minutes.
After completion of study, patients are followed up at 8-18 months.
Evaluating Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements for Oncologic Patients - A Cross-Sectional Survey Study at Norris Comprehensive Cancer Center
PRIMARY OBJECTIVES:
I. Identify how patients with cancer are obtaining nutrition to support medical management.
SECONDARY OBJECTIVES:
I. Examine associations of gastrointestinal side effects with specific diagnoses and
respective medical therapies.
II. Understand how patients access information regarding nutritional supplements.
III. Evaluate patient satisfaction with currently available oral nutritional supplements
(ONS).
IV. Identify patient preferences in formulating a novel nutritional supplement.
OUTLINE:
Participants attend an interview over 15 minutes and complete surveys.
Assessing Health Literacy and Interpreter Use in Radiation Oncology at LAC+USC Medical Center
PRIMARY OBJECTIVE:
I. To assess patient health literacy and understanding of critical radiation information
during consultation in Spanish and English speaking patient in the department of radiation
oncology at Los Angeles County (LAC) + University of Southern California (USC) utilizing a
patient survey administered after consultation.
SECONDARY OBJECTIVE:
I. Correlate findings of radiation comprehension and satisfaction with validated measures of
health literacy, acculturation, and socioeconomic status of patients.
TERTIARY OBJECTIVE:
I. To assess patient satisfaction of interpreter service in Spanish-speaking patients among
breast and prostate cancer patients receiving definitive radiation.
OUTLINE:
Patients complete a survey over 5-10 minutes about their understanding of radiation therapy.
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