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Open-label Phase 1/2 (Safety Lead-in) Study of Trans Sodium Crocetinate (TSC) With Concomitant Treatment of Fractionated Radiation Therapy and Temozolomide in Newly Diagnosed Glioblastoma (GBM) Patients to Evaluate Safety and Efficacy
The overall objectives of this Phase 1/2 clinical study in newly diagnosed GBM patients are
to evaluate the safety and tolerability, efficacy, PK profile, PFS/time to disease
progression, QoL, and overall survival in adults when TSC is added to the standard of care
regimen of radiation therapy and temozolomide. All patients will receive TSC in this study.
The primary objective of the Phase 1 portion of the study is to evaluate the safety (DLT
rate) and to define the dosing regimen of TSC for the larger Phase 2 study. The primary
clinical endpoint is overall survival at 24 months and patients will be followed for up to 3
years.
Not recruiting | Brain Cancer | Multisite
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Naveed Wagle
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