Effects of Oxytocin on Smoking
This study is examining the effects of a hormone called oxytocin on smoking. Oxytocin is a naturally occurring hormone in the brain and throughout the body In this study, oxytocin is experimental and is in the form of a nasal spray. We hope to learn if oxytocin nasal spray will help reduce the urge to smoke.
A Phase II, Multicenter, Randomized, Open-label Study to Investigate the Safety and Efficacy of Mycophenolate Mofetil and Rilonacept (Anti-interleukin-1) in Patients With Alcoholic Hepatitis
This is a prospective, randomized trial of two experimental treatments, prednisolone +
mycophenolate mofetil and prednisolone + rilonacept, in comparison with standard of care, in
patients with alcoholic hepatitis. Patients will start therapy with prednisolone. At Day 8
response to prednisolone will be determined using the Lille score. Patients with a Lille
score ≥ 0.45 will be randomized to standard of care (continue prednisolone, stop all therapy
and/or offer palliative care) or to have prednisolone continued and mycophenolate added for
the next three weeks. Patients with a Lille score <0.45 will be randomized to continue
prednisolone alone (standard of care) or to have rilonacept added to their treatment regimen
(experimental group) for the next three weeks. Patients will complete follow-up visits at
Week 12 and Week 24.
Powered by
SC CTSI