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Clinical Trials and Studies

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Study Title Principal Investigator
The Genetics of Liver Fat (GoLF): Contributions of Genes and Liver Fat to Diabetes Risk in Mexican Americans
<p>Diabetes affects millions of people in the United States, and Latinos are at higher risk. The liver plays an important role in regulating blood sugar. At the University of Southern California (USC), we are seeking participants for an ongoing study to investigate how differences in your genes impact liver fat levels, and how these levels affect diabetes risk. We want to improve the understanding of diabetes, obesity, and fatty liver disease, and work toward developing better ways to treat and prevent these diseases. </p><p>This is a collaborative study between Kaiser Permanente Southern California (KPSC) and the University of Southern California (USC), sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).</p>
Recruiting | Diabetes Type 2 | Not Multisite
Thomas A Buchanan, MD
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
Prevention of stroke involves managing and treating risk factors. Most strokes are caused when blood flow to a portion of the brain is blocked. One place this often happens is in the carotid artery. This blockage is called atherosclerosis or hardening of the arteries. The purpose of this trial is to determine the best way to prevent strokes in people who have a high amount of blockage of their carotid artery but no stroke symptoms related to that blockage. Each eligible participant will be evaluated to determine which procedure(s) is best for him/her. All participants will receive intensive medical treatment. In addition, participants will be randomized to receive the selected procedure or not. The trial will be conducted in the United States and Canada by physicians carefully selected on their ability to perform the procedures at low risk. Another key component of the trial is that important stroke risk factors, including hypertension, diabetes, high cholesterol, cigarette smoking, physical activity, and diet will be managed intensively. Participants will remain in the study for 4 years.
Recruiting | | Multisite
Thomas Brott
Assessing the Efficacy of Secukinumab in Psoriasis Patients
The purpose of the study is to see if secukinumab has an effect on fatty tissue beneath the skin and on skin inflammation in patients with psoriasis. This study will also look at blood tests, or “markers,” that could help identify risk for heart disease and metabolic diseases like diabetes or cardiometabolic disease. Secukinumab (Cosentyx®) is a prescription medicine that has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of moderate to severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis in adults.
Recruiting | psoriasis | Not Multisite
April W. Armstrong, MD MPH
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A Phase III, Double-blind, Randomized, Placebo-controlled, Multicenter Study to Asses the Safety and Efficacy of VM202 to Treat Chronic Nonhealing Foot Ulcers in Diabetic Patients With Concomitant Peripheral Arterial Disease (PAD)
A phase III, randomized, double-blind, placebo-controlled, multicenter, 7-month study designed to assess the safety and efficacy of intramuscular (IM) injections in the calf of VM202 in patients with chronic nonhealing foot ulcers. Three hundred patients will be randomized in a 2:1 ratio of VM202 or placebo injections: - Active -VM202 + standard of care - 200 patients - Control - Placebo (VM202 Vehicle) + standard of care - 100 patients
Recruiting | Atherosclerosis | Site Unknown
Emerson Perin
How the diet of breastfeeding Latina moms affects the health of their babies
This study looks&nbsp;at the effects of sugar in&nbsp;Hispanic/Latina&nbsp;moms and their babies. Previous studies have found that eating and drinking too much sugar can cause weight gain and health problems that affect the liver, kidneys, and heart. Feeding sugar to children can cause health problems that affect their growth and development.&nbsp;Hispanic/Latina moms and their babies are more at risk for these health problems than other groups. <strong>We want to find out&nbsp;whether an education program to reduce sugar improves the health of Hispanic/Latina moms and their babies.&nbsp;Come join the MAMITA Study if you are a pregnant or have a newborn.</strong>
Recruiting | diet | Not Multisite
Michael Goran, PhD
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