The goal of this study is to better understand how brain functioning relates to mood and eating behaviors in real life. You may be eligible if you experience binge eating or have difficulties controlling your eating behavior.
Alzheimer’s disease is a brain disease that affects memory, thinking, and behavior, and causes severe memory loss over time, known as dementia. Diabetes increases the risk of developing Alzheimer’s disease and related dementias. Latinos have a higher risk of developing both diabetes and Alzheimer's but are underrepresented in research. We are studying...
A prospective multicenter randomized blinded study comparing Aquablation of the prostate with the AQUABEAM System and TURP for the treatment of Lower Urinary Tract Symptoms (LUTS). The primary endpoints for safety and effectiveness will be measured at 3 and 6 months, respectively, and subjects will be followed out to 3...
The purpose of this study is to understand how individuals control their walking after stroke while using visual information about their walking and while walking at different speeds. We hope to learn how people learn new walking patterns when parts of the brain are damaged and how this may change...
Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity. CLI is a major cause of death and disability (secondary to myocardial infarction, stroke and amputation). The mortality in patients...
The purpose of this study is to understand how a stroke affects walking balance and why people post-stroke fall more frequently. Findings from this study could inform the design of rehabilitation interventions to improve post-stroke walking ability.
We are looking for people who have had a stroke AND healthy adults who...
Researchers at USC invite you, and your friends and family, to enroll online in USC GeneScreen, USC Alzheimer's Prevention Registry.
Alzheimer’s disease is a brain disease that affects memory, thinking, and behavior. It is a progressive brain disorder that causes severe memory loss over time, making it increasingly difficult for people...
The BenfoTeam Study is a multi-site clinical trial evaluating whether Benfotiamine, a form of vitamin B1, can help slow memory decline and support brain health in individuals with early Alzheimer's disease. Benfotiamine is thought to enhance brain energy metabolism and reduce biological changes linked to Alzheimer's, including inflammation and abnormal...
Atopic Dermatitis is a form of eczema that causes dry, scaly, itchy skin. More than 3 million cases are reported in the U.S. each year. People with this skin condition often have problems with bacterial skin infections caused by a specific bacteria known as, Staph aureus, or just Staph. Patients...
Seasonal influenza is responsible for approximately 226,000 excess hospitalizations annually and despite effective antivirals causes significant morbidity and mortality (estimated 24,000-50,000 deaths each year in the United States alone). The influenza virus that emerged in 2009 (A/California/07/2009 H1N1) caused fewer deaths (12,000 flu-related deaths in the U.S) but in contrast...
RXDX-101-01 is a multicenter, open-label, Phase 1/2a study in which the safety and efficacy of RXDX-101 will be evaluated in adult patients with any locally advanced or metastatic solid tumor. The primary objective of the Phase 2a expansion cohorts is Objective Response (OR) defined as Complete Response(CR) and Partial Response...
Depression is a major source of disability and distress worldwide. Some types of thinking patterns and feelings may be different in people with a history of depression. However, not enough is known about how the brain influences the way people feel, such as how people help themselves to feel better....
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices...
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
The Alzheimer Prevention Trials (APT) Webstudy is designed to accelerate enrollment into Alzheimer’s clinical trials by identifying and tracking individuals online, who may be at higher risk for developing Alzheimer’s. The Alzheimer’s Association estimates that 5.5 million Americans age 65 and older are currently living with Alzheimer’s dementia. It’s believed...
This is a randomized, double blind, placebo and active controlled, multicenter, parallel group Phase 3 study of the efficacy and safety of tanezumab when administered by SC injection for up to 56 weeks in subjects with chronic low back pain. Approximately 1800 subjects will be randomized to 1 of 4...
Multicenter, prospective, randomized, controlled feasibility trial to determine the safety and effectiveness of Dehydrated Human Amnion Chorion Membrane (dHACM) plus Control as compared to Control alone for the treatment of second degree burns as assessed by time to healing and scarring
RATIONALE: Heart failure is a major cause of morbidity and mortality. CardioMEMS HF System is an FDA approved implantable device that wirelessly measures and monitors pulmonary arterial pressure and heart rate. The CHAMPION trial demonstrated that management of heart failure using pulmonary artery pressure information obtained with the CardioMEMS HF...
This study is 24 month, multicenter study in 280 living donor liver transplant patients from Asia, Europe and Canada. The study also have an long term extension in Japan and approximately 28 patients will be included to evaluate the long-term efficacy and safety of concentration-controlled everolimus regimen plus reduced tacrolimus...
