Diagnosing Clinically Significant Prostate Cancer in African American and White Men

Purpose

Many men with prostate cancer do not need to receive treatment, only monitoring. Therefore, the first step in diagnosing prostate cancer is to do a prostate biopsy to determine whether treatment is needed or not, and to find the most appropriate treatment. Standard biopsy approaches can miss the most aggressive area of cancer, leading to under-diagnosis of disease. We are comparing two new protocols to diagnose prostate cancer that combine the use of imaging and image-guided biopsies, in addition to standard biopsy. Our goal is to improve the detection of clinically significant cancer, so that men can make more confident decisions about their treatment and follow-up.

Keywords: prostate, cancer, biopsy

Study Sites

Keck Hospital of USC; Norris Comprehensive Cancer Center 90033

 
  • Men
Age icon
40 years old and older
 
 

Contact the study team

 

What's involved?

Trial length
  • 12-48 months

Number of visits
  • 5-8

Prescription
  • None

Procedures
  • Blood draw

  • MRI

  • Prostate biopsy

Compensation
  • Compensation is available for completion of study surveys

Medical cost coverage
  • None. All procedures in this study are part of the standard of care for prostate biopsy

Why participate?

Medical advances are impossible without volunteers.

Eligibility

Must have


  • Male
  • Elevated Prostate Specific Antigen (PSA)
  • Eligible for prostate biopsy
  • Willing to undergo MRI
  • African-American or White men (Hispanic or Non-Hispanic)
  • 40 years old or older

Can't have


  • Had any surgery of the prostate
  • Had a positive prostate biopsy
  • Positive digital rectal exam

About This Study

Most prostate cancer patients are diagnosed with non-aggressive disease, which often does not require any treatment other than follow-up. Men diagnosed with more advanced disease can benefit from early interventions. Therefore, the prostate biopsy plays a crucial role in deciding whether treatment is needed, and if so, which is the best type. Unfortunately, standard biopsy approaches can miss the most aggressive area of cancer, leading to under-diagnosis of disease. This not only compromises treatment for those few who may have aggressive disease, but it can also reduce the confidence of those with indolent disease to avoid treatment. We wish to change the way in which prostate cancer is diagnosed to offer more confidence to men, so that they can make better treatment choices, with confidence and peace of mind. By combining the power of magnetic resonance imaging and more accurate targeted biopsies we hope to improve the detection of clinically significant prostate cancer. This study will allow us to determine which is the best order in which we should add these procedures in order to improve cancer detection. Each arm of the study will include these approaches in a different order. You may or may not receive any personal benefit. We think that by participating in this trial we will be more likely to determine if you have cancer or not as we will be performing additional procedures that have shown to improve cancer detection (MRI, MRI-guided biopsies). However, there is no guarantee you will receive any benefit from taking part in this study.

Study video which is shown to all prospective participants


Click here: https://drive.google.com/drive/folders/0B5Q7FISVTvWWR05sWXE1TjF4aGc?usp=sharing

Study team

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Principal Investigator
Inderbir S. Gill, MD
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Principal Investigator
Mariana C. Stern

For questions about this study, contact:

  • Study Coordinator Mustafa Deebajah
  • Detroit, Michigan
  • (313) 916-5643
  • MDeebaj1@hfhs.org

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