Effect of lifestyle on mild cognitive impairment in Parkinson's disease


Thinking problems are common in Parkinson’s disease and lead to poor quality of life. The purpose of this study is to see if exercise is helpful to improve thinking problems in Parkinson’s disease. When people with Parkinson’s disease have thinking problems, their ability to make decisions or plan events may be challenging. This may include the ability to move, walk safely, and maintain normal balance.

Keywords: Parkinson's disease, exercise, brain

Study Sites

Keck School of Medicine, Los Angeles, USC 90089

  • Men & Women
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Contact the study team


What's involved?

Trial length
  • 12 weeks

Number of visits
  • 45 (3 hours per week)

  • Socialization or Exercise

  • Questionnaires

  • Fitness testing

  • Functional Magnetic Resonance Imaging (fMRI)

  • None

Medical cost coverage
  • None

Why participate?

Many clinical studies face critical delays due to lack of participation. Be a part of the solution!


Must have

  • Confirmed diagnosis of Parkinson's disease
  • Complaints of thinking of memory problems
  • Medically eligible for MRI imaging
  • Able to provide a written medical clearance from their primary physician to participate in exercise
  • Stable dosages of PD medications for 3 months

Can't have

  • History of severe cardiac disease
  • History of an abnormal stress test
  • Electrically, magnetically, or mechanically activated implant (such as cardiac pacemakers or intracerebral vascular clip)
  • Past history of brain lesions (such as stroke)
  • Seizures or unexplained spells of loss of consciousness
  • Family history of epilepsy
  • Diagnosis of Parkinson's disease dementia

About This Study

Currently there is no effective treatment for thinking problems in Parkinson’s disease. Very few studies have been done to test the effects of exercise on thinking problems in Parkinson's disease. With help from our participants, in this study we will compare three different lifestyle interventions, socialization and two different types of exercise to see if exercise has any effect on brain activity in patients with Parkinson’s disease that might be helpful for thinking problems.

Study team

7i6gt9i5r66mdw9hbhvl Collaborate with the PI

For questions about this study, contact:

Research study materials

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