294 studies found

New study seeks to understand how the brain optimizes walking in older adults

The purpose of this study is to understand how people control walking and balance. We are looking for healthy older adults who are interested in joining the study. Participants will walk on a treadmill while using an interactive display that will help them modify their walking pattern. We will determine how these modifications...

An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis

This is a multicenter, randomized open-label Phase 2 study to assess the safety, efficacy and pharmacokinetic (PK) of 2 dosing regimens of encorafenib + binimetinib combination in patients with BRAFV600-mutant melanoma with brain metastasis. Approximately 100 patients will be enrolled, including 9 patients in a Safety Lead-in of the high-dose...


A pilot study of safety and adequacy of pancreatic lesion biopsy (Spy Bite)

The purpose of this study is to determine the safety and effectiveness of an experimental technique to obtain biopsies of pancreatic lesions. This technique uses biopsy forceps, which are small jaw-like devices that open and close, to also obtain tissue samples for examination and diagnosis. The biopsy forceps will pass...


Help stroke survivors! Join research study on motion, balance and walking

85% of survivors of stroke experience walking issues, which limit their activities and participation. These issues include decreased coordination and slower walking, which might make people more prone to falls.

The objective of this study is to measure walking in people shortly after stroke and to identify which aspects...


Lean on me: Research Study for Couples Trying to Stop Smoking

If you are trying to quit smoking cigarettes, it may be more difficult if your significant other also smokes. Researchers at USC would like to understand whether having a romantic partner who also smokes affects a smoker's attempts to quit. What we learn will help us to develop more...


Sweet PEA Study: How the diet of pregnant women affects the growth and development of their babies

This study looks at how what pregnant women eat and drink affects the growth and development of their babies. We’re looking for pregnant women in Los Angeles who are interested in joining our study. Joining the study is easy and monetary compensation for participation is available.


Testing a new drug to prevent Alzheimer's disease and dementia

Do any of your friends, family, or loved ones have problems remembering or have developed Alzheimer’s disease? The USC Alzheimer Disease Research Center is testing how well a drug may help to prevent the loss of memory. The research team is looking for volunteers (ages 60 to 75) who do...


Testing a new drug to reduce anxiety and agitation in people with Alzheimer's disease and dementia

A person with Alzheimer's often feels anxious or upset easily. They might be restless, unable to sleep or pace back and forth. These problems, called agitation, can keep them from a normal day-and-night routine and might become harmful for your loved one or their caregivers.

Can FDA-approved medication that treats...


USC study investigates the benefits or health risks of vaping and smoking

Researchers at USC are seeking study participants who vape or smoke as well as non-smokers in the Los Angeles area. The purpose of the research is to study the health benefits and risks of electronic cigarettes (e-cigs). Your participation will help to better understand the potential effects of e-cigs on...


A pilot study of safety and efficacy of spectroscopic diagnosis of pancreatic lesions (Spy Panc)

The objective of this study is to determine if a minimally invasive optical probe can accurately predict a histological diagnosis of dysplastic or malignant tumor cells in solid lesions of the pancreas. If effective, this optical probe would facilitate the detection of malignant and pre-malignant pancreatic lesions. This would lead...

A Phase II Study of Sodium Cridanimod in Conjunction With Progestin Therapy in Patients With Progesterone Receptor Negative Recurrent or Persistent Endometrial Carcinoma

This is an open label, multi-center, single arm phase II study. The study will investigate the efficacy of sodium cridanimod in conjunction with progestin therapy in a population of patients with recurrent or persistent PrR-negative endometrial cancer. Eligible patients will be enrolled into the study and administered sodium cridanimod in...


Does pulling out work for birth control?

Why Withdrawal?

“Pulling out” or withdrawal is a method that people use to prevent pregnancy. It's been around for a long time and lots of people use it. However, we--scientists--STILL don't know very much about how to use it and how effective it really is. Some men have used withdrawal their whole lives...

A Clinical Study of Patients With Symptomatic Neurogenic Orthostatic Hypotension to Assess Sustained Effects of Droxidopa Therapy

This is a multi-center, multi-national, randomized, parallel-group, placebo-controlled, double-blind study with a 17 week (maximum) treatment period consisting of an initial, open-label dose titration (up to 2 weeks), followed by a washout period (up to 3 weeks), followed by a 12 week treatment period on a stable dose.


All of Us Research Program

The mission of the All of Us Research Program is simple. We want to speed up health research and medical breakthroughs. To do this, we’re asking one million or more people to lead the way to provide the types of information that can help us create individualized prevention, treatment,...

Vascular Inflammation in Psoriasis - Apremilast

The primary objectives of this study are to determine the effect of apremilast on aortic vascular inflammation, cardiometabolic biomarkers and body composition in patients with moderate-severe psoriasis. FDG-PET/CT will be used to assess vascular inflammation, with multi-volumetric product, tissue-to-background ratio and total atherosclerotic burden, and body composition via volumetric quantification....

Light Treatment Effectiveness (LITE) Study

The primary objective of this study is to compare the effectiveness, safety (tolerability), and duration of treatment response at 12 weeks of home versus office-based narrowband ultraviolet B phototherapy for the treatment of psoriasis. Physician Global Assessment (PGA) and Dermatology Life Quality Index (DLQI) will be used to assess effectiveness,...

⁸⁹Zr-Df-IAB22M2C (CD8 PET Tracer) for PET/CT in Patients With Metastatic Solid Tumors

Protocol IAB-CD8-201 is a Phase II, Open Label, Multi-Dose Study of ⁸⁹Zr-Df-IAB22M2C (CD8 PET Tracer) for Positron Emission Tomography (PET/CT) in Patients with Advanced or Metastatic Melanoma, Non-Small Cell Lung Cancer, Renal Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck Selected to Receive Standard-of-Care Immunotherapy as Single Agent...


Effect of ResQFoam to Slow or Stop Severe Internal Bleeding in Trauma Patients

Trauma is the leading cause of death in people younger than 45 years. Unfortunately, 40-50% of severely injured patients with internal bleeding die, even after reaching the hospital. This clinical study is about whether ResQFoam can help slow or stop severe internal bleeding in the abdomen (belly area) while the...


Healthy Minds Volunteer Database

The Healthy Minds Volunteers (http://healthyminds.usc.edu) help research labs at the University of Southern California. These labs are working towards a greater understanding of how aging can affect physical, mental and emotional health. The goal is to learn how we can maintain healthy minds and bodies across our lifespan.

An Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease

An Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease


A Placebo-controlled Study of a Targeted Immune Therapy Drug in Subjects with Moderate to Severe Ulcerative Colitis (UC)

The primary objective of this study is to study the effectiveness of a novel targeted immune therapy (biologic) called LY3074828 in treating moderate to severe ulcerative colitis. This study will take place over 120 weeks and all study visits and procedures will be provided at no cost to you. During...

Long-Term Registry of Patients with Urea Cycle Disorders (UCDs)

The main goal of medical management of Urea Cycle Disorder (UCD) patients is to prevent chronic or acute hypperammonemic states leading to central nervous damage- which requires a restriction in dietary protein intake and using nitrogen scavenging agents if diet alone does not help the patients.The objective of this study...